This study examined the relationship between types of overexcitability (OEs), Big Five dimensions, and giftedness. A sample of intellectually gifted adolescents (N = 132) and controls (N = 103) completed the OEQ-II and the NEO-FFI. As hypothesized, the gifted scored higher than controls on intellectual OE, imaginational OE, and openness to experience but lower on neuroticism. Contrary to expectations, group- related differences were found for sensual OE, but not for emotional OE. Moreover, SEM analysis showed that giftedness moderated the relation of OEs with openness and extraversion. The relations between sensual OE and openness as well as between psychomotor OE and extraversion were stronger in the gifted than in controls. Relationships between sensual, intellectual, imaginational OEs and extraversion turned out to be significant only in the controls.