The nature of the relationship between creativity and personality is one of the core issues at the heart of creativity research. It is a rare topic that can both inspire a kneejerk, obvious response (such as “Openness to experience is related to creativity,” a near-universal finding) (see J.C. Kaufman 2016) yet also present intricacies and debates such that the topic warrants a full handbook. A scan of the table of contents of this book gives a hint of the scope of this issue. In this chapter we tackle two related areas that play into the larger creativity-personality connection: creativity domain and mood.